Major part of musculoskeletal injuries involve tendon and ligament injuries. Improved treatments are still needed in order to address several issues arising post-operatively like re-rupture, adhesion formation and insufficient mechanical properties of the tissues. Taking this into account, new emulsion electrospun double-layered tube, based on an elastic and biodegradable block copolymer (DegraPol®), delivering growth factors, more specifically PDGF-BB in a sustained manner has been developed. Aimed to be used for tendon rupture repair application, it allows sustained delivery of bioactive PDGF-BB, thus promoting tenocyte proliferation in vitro, while still retaining some of its mechanical properties and allowing proper operational and surgeon friendly handling.
Evrova, O. et al. Bioactive, Elastic, and Biodegradable Emulsion Electrospun DegraPol Tube Delivering PDGF-BB for Tendon Rupture Repair. Macromolecular Bioscience. doi: 10.1002/mabi.201500455