Today biomaterials are initially tested by analysis of the in vitro interaction of the material with single cell types. These simplified test conditions do not account for that in vivo implants get exposed to blood, immune cells, and further cell types during implantation and subsequent healing. Here, we used surfaces of dental implants to show that only the interaction of implant-adhering blood with other cell types causes an increase of factors important for fast wound healing. To increase the predictability of in vitro tests for the in vivo performance of biomaterials, we suggest including initial blood-implant contact in in vitro test platforms.
Original publication: MA Burkhardt et al. Synergistic interactions of blood-borne immune cells, fibroblasts and extracellular matrix drive repair in an in vitro peri-implant wound healing model. Scientific Reports. doi: 10.1038/srep21071
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