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Research Spotlight

Initial blood contact of implants drives wound healing response

2016
False-colored scanning electron micrograph depicting how fibroblasts (brown) interact with a blood clot (fibrillar structures, grayscale, and red blood cells, red), which was formed on a rough titanium implant surface upon initial contact with human blood.

Today biomaterials are initially tested by analysis of the in vitro interaction of the material with single cell types. These simplified test conditions do not account for that in vivo implants get exposed to blood, immune cells, and further cell types during implantation and subsequent healing. Here, we used surfaces of dental implants to show that only the interaction of implant-adhering blood with other cell types causes an increase of factors important for fast wound healing. To increase the predictability of in vitro tests for the in vivo performance of biomaterials, we suggest including initial blood-implant contact in in vitro test platforms.

Original publication: MA Burkhardt et al. Synergistic interactions of blood-borne immune cells, fibroblasts and extracellular matrix drive repair in an in vitro peri-implant wound healing model. Scientific Reports. doi: 10.1038/srep21071

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tex

9.5.2016
Cameron's paper about the enhanced differentiation of embryonic stem cells got published.

Congratulations! Now available in Scientific Reports.

Oli

13.4.2016
Olivera's paper about electrospun DegraPol tube delivering PDGF-BB for tendon rupture repair application got published.
Congratulations! Now available in Macromolecular Bioscience.

MD

4.4.2016
Florian‘s paper about improved MARTINI simulations of protein-lipid interfaces got published.
Congratulations! Now available in the Journal of Chemical Theory and Comuptation.

yo

4.4.2016
Seminar by Prof. Yo Tanaka [RIKEN, Japan] entitled: "Cardiomyocyte devices and cell patterning techniques"
The seminar takes place Monday, April 4 at 2:30 pm in the painted room.  

eric

1.4.2016
Seminar by Prof. Eric Dufresne [ETH, Zurich] entitled: "Self Assembly and Mechanics of Living Systems"
The seminar takes place Friday, April 1 at 10:30 am in the painted room.

li

16.3.2016
Seminar by Dr. Bojun Li [AO Fundation, Switzerland] entitled: "Monitoring live human mesenchymal stem cell differentiation"
The seminar takes place Wednesday, March 16 at 11:30 am in the painted room.

Melanie

17.2.2016
Melanie's paper about synergistic interactions of blood cells and implant materials got published
Congratulations! Now available in Scientific Reports

medal

15.1.2016
Dr. Lina Aires has been awared the ETH Medal
Congratulations! For her outstanding doctoral thesis Lina Aires was awarded with the ETH Medal.

ima

5.1.2016
Ima's paper about how fimbriated bacteria evade antibiotics got published
Congratulations! Now available in Scientific Reports

Maria

21.12.2015
Maria's paper about endothelial cell migration along fibronectin fibers got published.
Congratulations! Now available in   PLoS ONE

phil

15.12.2015
The review about the shaping of tissues by force-geometry balance got published
Congratulations! Now available in Journal of Physics D: Applied Physics.

 
 
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